|
|
|
|
In 13 patients,a diagnosis of adult metachromatic leukodystrophy was made. The main symptoms were dementia,behavioral abnormalities,ataxia,and polyneuropathy.In 12 patients,a diagnosis of arylsulfatase A pseudodeficiency was made.No characteristic clinical syndrome could be detected in these patients.Adult metachromatic leukodystrophy is a progressive metabolic disease with symptoms of demyelination of the central and peripheral nervous systems.Diagnosis must be confirmed by determination of arylsulfatase A activity and accumulation of sulfatides. Pseudodeficiency for arylsulfatase A can be confirmed or excluded by means of DNA analysis. |
|